Early Oral & Topical Anti-inflammatory Therapies for IBD
Methylprednisolone / Taro Pharmaceuticals Inc. (2021)
Ulcerative colitis–hospitalized patients with acute severe disease.
Crohn’s disease–hospitalized patients with acute severe disease.
IV
40–60 mg/24 hours.
Dosing may vary between institutions.
Hospitalized acute severe ulcerative colitis
IV 1 to 1.5 mg/kg
To a max of 60 mg/day
Divided into one or two daily doses.12
RCTs: randomized clinical trials, IV: intravenous, BDP: beclomethasone dipropionate
For more detailed information regarding side effects, please refer to the appropriate product monograph.
• Adrenal suppression
• Bone growth inhibition in pediatric population
• Mood changes
• Cushing syndrome
• Peptic ulcer
• Hyperglycemia
• Increased risk of infection
• Osteoporosis
• Glaucoma
IBD: inflammatory bowel disease
Severe ulcerative colitis should be treated with intravenous steroids.12
Recommendations15:
All available data indicate a higher risk of serious adverse events with prolonged use of corticosteroids in elderly patients with IBD when compared to younger adult patients.
Increased risk of infections, Osteoporosis-related fractures, alteration in mental status, fluid retention, ocular problems and drug interactions.
Coming soon
Coming soon
IBD: inflammatory bowel disease, 5-ASA: 5-aminosalicylic acid, ECCO: European Crohn’s and Colitis Organization, EEN: enteral nutrition